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Welcome to the Therakos Institute

TKS Institute TM CMYK 2022

At the Therakos Institute, our primary goal is to advance knowledge and understanding around Extracorporeal Photopheresis (ECP) immunomodulation. We have forged valuable partnerships with leading experts from around the world, regularly bringing our best and brightest together to provide accessible education to HCPs. Through these collaborations, we aim to build a better future for patients.

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Webinars

Up-to-date coverage of a broad range of topics related to scientific, regulatory, economic and technical aspects of ECP.

Explore our webinars

Symposia V2

Symposia

Major thought leaders present on specific topics on the latest in ECP Immunomodulation – guaranteed to be both stimulating and informative.

Symposia

Centres Excellence V2

Centres of Excellence

We partner with several European Centres of Excellence (CoE) to provide high-quality professional education to committed healthcare professionals.

Centres of Excellence

Speaker Meetings V2

Speaker meetings

The latest scientific knowledge and advancements in ECP brought to life in conversation by major thought leaders.

Speaker Meetings

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Ask the Expert

Private, one-to-one sessions with leading experts in their respective fields of relevance to ECP and its clinical applications.

Ask the Expert

Upcoming Events

CoE Course

Sep 26 - 27, 2023

Interactive Workshop on Lung Transplant Rejection

Vienna University Hospital, Vienna, Austria

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CoE Course

Sep 27 - 28, 2023

Interactive Workshop on Dermatological Diseases

Vienna University Hospital, Vienna, Austria

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CoE Course

Sep 28 - 29, 2023

THERAKOS CELLEX Photopheresis System Practical Course

The Tirol Kliniken, Innsbruck, Austria

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Speaker Meeting

Oct 3, 2023

How to improve overall survival in acute GvHD by applying ECP

Nottingham, UK

Symposium

Oct 5, 2023

UKPS 2023 Clinical Symposium: Save the Date

London, UK

CoE Course

Oct 10 - 11, 2023

Interactive Workshop on Treating GvHD

University Medical Center (UKE) and University Heart Center (UHZ), Hamburg, Germany

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Symposium

Oct 11, 2023

FOKUS 2023 Clinical Symposium: Save the Date

Stockholm, Sweden

Speaker Meeting

Oct 12 - 13, 2023

French Operator Days
This event is in French

Paris, France

Symposium

Oct 19, 2023

COSTEM 2023: Meet The Expert Session

Berlin, Germany

Symposium

Oct 19, 2023

Austrotransplant 2023 Clinical Symposium: Save the Date

Eisenstadt, Austria

CoE Course

Oct 30 - 31, 2023

A–Z of Treating Patients with ECP – The Nordic Approach (1)

The Oslo University Hospital, Oslo, Norway

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Speaker Meeting

Nov 7, 2023

Extracorporeal photopheresis and chronic graft-versus-host disease

Rome, Italy

Speaker Meeting

Nov 23 - 24, 2023

3rd Therakos “3-Country Meeting”

Vienna, Austria

CoE Course

Nov 30 - Dec 1, 2023

THERAKOS CELLEX Photopheresis System Practical Course 

The Tirol Kliniken, Innsbruck, Austria

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Symposium

Dec 7, 2023

SFT 2023 Clinical Symposium: Save the Date

Brest, France

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Developing leadership in healthcare

An SDA Bocconi course.

Sponsored by Mallinckrodt.

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Brilliant Speakers

Our communication course dedicated to bringing
our leaders into the new era of engagement.

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Important Safety Information
For the TherakosTM Photopheresis
Procedure

Indications

The THERAKOSTM CELLEXTM Photopheresis System is indicated for the administration of photopheresis. Please refer to the appropriate product labelling for a complete list of warnings and precautions.

Contraindications

THERAKOSTM Photopheresis is contraindicated in:

  • Patients possessing a specific history of a light sensitive disease.
  • Patients who cannot tolerate extracorporeal volume loss or who have white blood cell counts greater than 25,000 / mm3.
  • Patients who have coagulation disorders or who have previously had a splenectomy.

Warnings and Precautions

THERAKOSTM Photopheresis treatments should always be performed in locations where standard medical emergency equipment is available. Volume replacement fluids and/or volume expanders should be readily available throughout the procedure. Safety in children has not been established.

  • Do not expose the device to a magnetic resonance (MR) environment. The device may present a risk of projectile injury, and thermal injury and burns may occur. The device may generate artifacts in the MR image, or may not function properly.
  • Thromboembolic events, including pulmonary embolism and deep vein thrombosis, have been reported in the treatment of Graft versus Host Disease (GvHD). Special attention to adequate anticoagulation is advised when treating patients with GvHD.
  • When prescribing and administering THERAKOSTM Photopheresis for patients receiving concomitant therapy, exercise caution when changing treatment schedules to avoid increased disease activity that may be caused by abrupt withdrawal of previous therapy.

Adverse Events

  • Hypotension may occur during any treatment involving extracorporeal circulation. Closely monitor the patient during the entire treatment for hypotension.
  • Transient pyretic reactions, 37.7–38.9°C (100–102°F), have been observed in some patients within six to eight hours of reinfusion of the photoactivated leukocyte-enriched blood. A temporary increase in erythroderma may accompany the pyretic reaction.
  • Treatment frequency exceeding labelling recommendations may result in anaemia.
  • Venous access carries a small risk of infection and pain.

Please refer to the THERAKOSTM CELLEXTM Photopheresis System Operator Manual for a complete list of warnings and precautions.

IMPORTANT SAFETY INFORMATION FOR METHOXSALEN USED IN CONJUNCTION WITH THERAKOSTM PHOTOPHERESIS

Contraindications

Methoxsalen is contraindicated in:

  • Patients exhibiting idiosyncratic or hypersensitivity reactions to methoxsalen, psoralen compounds, or any of the excipients
  • Patients with co-existing melanoma, basal cell or squamous cell skin carcinoma
  • Patients who are pregnant, and sexually active men and women of childbearing potential unless adequate contraception is used during treatment
  • Patients with aphakia because of the significantly increased risk of retinal damage due to the absence of a lens

Warnings and Precautions

  • Special care should be exercised in treating patients who are receiving concomitant therapy (either topically or systemically) with known photosensitizing agents.
  • Oral administration of methoxsalen followed by cutaneous UVA exposure (PUVA therapy) is carcinogenic.
  • Patients should be told emphatically to wear UVA absorbing, wrap-around sunglasses for twenty-four (24) hours after methoxsalen treatment. They should wear these glasses any time they are exposed to direct or indirect sunlight, whether they are outdoors or exposed through a window.
  • Safety in children has not been established.

Refer to the package insert for methoxsalen sterile solution (20 micrograms / mL) or the oral 8-methoxypsoralen dosage formulation for a list of all warnings and precautions.

Please refer to the THERAKOSTM CELLEXTM Photopheresis System Operator Manual for a complete list of warnings, precautions and adverse events.

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Applications for the 2022 EIA are now closed.
The 2022 ECP Immunomodulation Investigator Award has been awarded to Professor Andrew Fisher, Professor of Respiratory Transplant Medicine at Newcastle University, and Honorary Consultant Respiratory and Transplant Physician at The Newcastle upon Tyne Hospitals NHS Foundation Trust's Institute of Transplantation. The objective of his project is to perform an in depth mechanistic assessment of Extracorporeal Photopheresis (ECP) treatment in patients suffering from Chronic lung Allograft Dysfunction (CLAD).

Full details are available on our press release page.

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